You Don't Know Jack begins as 61-year-old former pathologist Dr. Jack Kevorkian (Al Pacino) launches his crusade to provide what he considers to be a humane an dignified option for the terminally ill - assisted suicide. Aided by his loyal friend (John Goodman) ans his older sister (Brenda Vaccaro), Kevorkian begins offering his "death counselling" services to a grateful and burgeoning clientèle.